A Quantitative Structure–Activity Relationship (QSAR) for a Draize Eye Irritation Database
نویسندگان
چکیده
منابع مشابه
Draize Eye Irritancy Test Rabbits
Household products, shampoos, pesticides, weed killers, even riot control gases, are just some of the products tested for irritancy in the eyes of conscious rabbits. The Draize test, introduced in 1944, is cruelly simple. The substance under test is sprayed or instilled into one eye of an albino rabbit. Generally no pain relief is given and the test often proceeds for 7 days during which the co...
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QSAR models are frequently used to investigate and predict the toxicological effects of chemicals. Building QSAR models of the eye irritation potential of cationic surfactants is difficult, as the mechanism of action of these surfactants is still not fully understood. This report describes a data driven QSAR model to predict Maximum Average Scores (MAS in accordance to Draize) for cationic surf...
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Correspondence : Michiru Genno, Technical Research Laboratory, Kurabo Industries Ltd., 14-5 Shimokidacho Neyagawa-shi, Osaka 572-0823, Japan. Tel.: +(81) 720 23 8800, Fax: +(81) 720 23 7906, E-mail: [email protected]
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ژورنال
عنوان ژورنال: Toxicology in Vitro
سال: 1998
ISSN: 0887-2333
DOI: 10.1016/s0887-2333(97)00117-3